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. 2022 Nov 1;132(21):e158869. doi: 10.1172/JCI158869

Figure 7. Inflammation impairs cell maturation in Samd9l-Mut mouse.

Figure 7

(A–D) scRNA-seq of WBM and Lin–cKit+ (LK) sorted cells from Samd9l-WT or Samd9l-Mut mice treated with either pI:pC or vehicle. (A) UMAP plots of scRNA-seq data showing 5 main populations. (B) A circular plot showing the proportion of the identified 17 clusters from each WBM sample relative to WBM from Samd9l-WT control. (C) A circular plot showing 8 clusters from LK sorted samples. (D) A heatmap of the proportion of cells in each erythroid maturation stage is denoted as megakaryocyte/erythroid progenitor (MEP), early erythroid (Ery 1), and late erythroid (Ery 2). Among the compared groups, red indicates higher levels and blue indicates lower levels, and values represent the percentage of total cells. (E) BM cross sections (magnification, ×40) from Samd9l-WT or Samd9l-Mut mice treated with pI:pC or vehicle stained with anti-GATA1 antibody.