Table 2.
Drugs targeting PGR, SIRT1 and ADAMTS1 from DGIdb.
| Gene | Drug | Interaction Type & Directionality | PMIDs | Score |
|---|---|---|---|---|
| PGR | ULIPRISTAL | modulator | 23437846 | 5.7 |
| LEVONORGESTREL | agonist, modulator, binder | 17484506 17531625 17077229 16157482 11752352 16084894 | 4.18 | |
| DYDROGESTERONE | agonist | 6827166 436795 11752352 16045524 8486204 15128769 | 4.18 | |
| DESOGESTREL | agonist | 6645495 3139361 11041225 11752352 7750284 10601100 | 2.85 | |
| DROSPIRENONE | agonist | 7625729 8922878 16291771 17000933 16157482 15493951 11024226 | 2.85 | |
| NORELGESTROMIN | agonist | 17107221 1324557 19962254 7750291 8384965 | 2.66 | |
| ETONOGESTREL | agonist | 15063480 11041225 11752352 10601100 | 2.28 | |
| NORGESTIMATE | agonist | 17107221 1324557 11752352 7750291 8384965 | 2.05 | |
| NORETHINDRONE | agonist | 15063480 15261304 10494488 15189034 7711211 11752352 16084894 | 1.52 | |
| ETHYNODIOL DIACETATE | agonist | 166800 858280 11752352 | 1.52 | |
| ONAPRISTONE | antagonist | None found | 1.14 | |
| ULIPRISTAL ACETATE | modulator | None found | 1.14 | |
| DIENOGEST | agonist | 18061638 | 1.14 | |
| NORGESTREL | agonist, binder | 11521119 | 0.76 | |
| NORETHYNODREL | agonist | None found | 0.57 | |
| NORETHINDRONE ACETATE | agonist | None found | 0.57 | |
| MIFEPRISTONE | agonist, antagonist | 10699595 10682471 10374120 10806733 11783365 11752352 | 0.57 | |
| MEDROXYPROGESTERONE ACETATE | agonist | 12846422 | 0.41 | |
| DANAZOL | agonist | 17636649 2404115 8000225 18061638 | 0.36 | |
| TOREMIFENE | n/a | 2147123 | 0.33 | |
| ERIBULIN | n/a | None found | 0.33 | |
| GOSERELIN | n/a | None found | 0.33 | |
| HYDROXYPROGESTERONE CAPROATE | agonist | None found | 0.28 | |
| MEGESTROL ACETATE | agonist | None found | 0.28 | |
| PERTUZUMAB | n/a | None found | 0.28 | |
| ANASTROZOLE | n/a | None found | 0.24 | |
| LETROZOLE | n/a | None found | 0.23 | |
| PROGESTERONE | agonist | 17109827 9506743 21315613 17138644 17013809 17015480 17169175 30013421 | 0.22 | |
| NERATINIB | n/a | None found | 0.21 | |
| FULVESTRANT | n/a | None found | 0.16 | |
| EXEMESTANE | n/a | None found | 0.16 | |
| RIBOCICLIB | n/a | None found | 0.14 | |
| IXABEPILONE | n/a | None found | 0.11 | |
| BUDESONIDE | agonist | None found | 0.09 | |
| TAMOXIFEN | n/a | 3793272 | 0.09 | |
| TRASTUZUMAB | n/a | None found | 0.09 | |
| LAPATINIB | n/a | None found | 0.08 | |
| ABEMACICLIB | n/a | None found | 0.08 | |
| OLAPARIB | n/a | None found | 0.08 | |
| SIROLIMUS | n/a | 1284044 | 0.04 | |
| DOCETAXEL | n/a | None found | 0.03 | |
| PALBOCICLIB | n/a | None found | 0.02 | |
| SIRT1 | NIACINAMIDE | n/a | 25884115 | 1.64 |
| ADAMTS1 | PRAVASTATIN | n/a | 18174457 | 3.65 |