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. 2022 Oct 26;11(1):2474–2484. doi: 10.1080/22221751.2022.2130101

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Study design and two-dose BBIBP-CorV vaccination elicit diverse humoral immune responses. (A) Diagram of the study groups. A total of 84 participants were included for the analysis of virus-specific neutralizing antibodies 28 days (28dpp) and 6 months (6mpp) after the completion of the vaccination regimen. Immune profiles were also measured on 6mpp. Forty-seven participants exhibited a sustained level of neutralizing antibodies (Vac-Pos/SS); 22 participants lost their neutralizing antibody level at 6mpp (Vac-Pos/SD); 15 participants never showed the presence of neutralizing antibody (Vac-Neg). (B) Levels of wildtype (WT) spike (S)-specific neutralization antibody were compared between Vac-Pos and Vac-Neg groups at 28dpp. The lowest serum dilution tested was 1:4; undetectable pVNT50 values were set at a pVNT50 of 2. GMTs are indicated above the graph. (C) Levels of WT S-specific neutralizing antibody were analysed early (28dpp) and late (6mpp) after the 2-dose vaccination. Lines and bars indicated median with interquartile range (IQR). P value determined by unpaired t-test (B) or by paired t-test (C).