TABLE 2.
EC80 values from neuroimaging studies.
| References | No of subjects (males in%) | Mean age ± SD (years), if not specified other | Indication | Country | Steady state | EC80 in ng/ml | Brain region |
| Arakawa et al. (33) | 16 (50) | 29.1 ± 4.6 | HV | Japan | no | 16.0 | Thalamus |
| Kim et al. (35) | 12 (100) | 23.0 ± 2.7 | HV | Korea | no | 17.2* 11.6* |
Putamen DRN |
| Lanzenberger et al. (38) | 10 (40) | 42.3 ± 7.8 | MDD | Austria | yes | 17.5** | Thalamus |
*SPECT study (semiquantitative); **Data derived from Baldinger et al. (47). DRN, Dorsal raphe nucleus; HV, healthy volunteers; MDD, major depressive disorder.