TABLE 4.

Expected ESC concentration [ng/ml] based on combined mean C/D ratio.

Author, year	Reference group	Dx	n	Mean	Combined mean C/D ratio*	5 mg/day	10 mg/day	15 mg/day	20 mg/day	25 mg/day
Reis et al. (22)	Somatically not healthy	mDx	45	1.67	1.23	6	12	18	25	31
	somatically healthy		89	1.00
Reis et al. (21)	10 mg dose	mDx	1470	1.14	1.09	5**	11**	16**	22**	27**
	20 mg dose		883	1.00
Scherf-Clavel et al. (23)	Smokers	mDx	36	1.69	2.22	11**	22**	33**	44**	56**
	Non-smokers		88	2.44
Warrings et al. (24)	in- and outpatients	mDx	104	2.47	2.47	12**	25**	37**	49**	62**
Hiemke et al. (4)	young, male and female, somatically healthy	mDx	NA		1.05	5**	11**	16**	21**	26**

Dx: diagnose; mDx: multiple psychiatric diagnosis; N: naturalistic study setting, * [ng/ml/mg/day]. **Expected ESC concentration [ng/ml] based on the combined mean C/D ratio at administered dose [mg/day].