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. 2022 Oct 17;9:913869. doi: 10.3389/fcvm.2022.913869

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Copyright © 2022 Wang, Wang, Yang, Liu, Shen, Sun, Zhou, Fang and Ge.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lipoproteins metabolism and the arterial wall. Chylomicrons of different sizes needed to be converted into metabolic remnants, while VLDL needed to be metabolized to LDL to be cleaned. After being digested, CM and VLDL entered into the plasma and began to be lipolysis by lipoprotein lipase. Then CM remnants and VLDL remnant-like particles with higher density and smaller molecular weight were formed, respectively. Lipoproteins larger than 75 nm were not easily available to get across the arterial intima, such as chylomicrons. LPL, lipoprotein lipase; HL, hepatic lipase; VLDL, very-low-density lipoprotein; IDL, intermediate-density lipoprotein; LDL, low-density lipoprotein; FFA, free fatty acid; RC, remnant cholesterol.