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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Curr Opin Neurobiol. 2022 Feb 17;73:102515. doi: 10.1016/j.conb.2021.12.002

Figure 1: A physically invariant network with dynamic activity.

Figure 1:

A. Sensory circuit at 3 different developmental stages. Circles represent neurons, while lines represent chemical synapses. Only chemical synapses were mapped in Witvliet et al. B. Heatmap of neuronal activity measured by NLS-GCaMP5k fluorescence. Image is reproduced from Kato et al. C. A large fraction of neuronal activity from B represents the motor program. Most dynamics lie along a manifold in the first 3 principal components from PCA dimension reduction of neuronal activity (left panel). Manifold is colored according to the motor phase (right panel). Images are reproduced from Kato et al. D. Interneuron circuit. Certain neurons like AVB and RIB strongly correlate with forward behavior while neurons like AVA and RIM strongly correlate with reversal behavior. However, other interneurons like AIA, AIB, AIY and AIZ transiently correlate with motor state.