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. Author manuscript; available in PMC: 2023 Oct 28.
Published in final edited form as: J Nat Prod. 2022 Sep 29;85(10):2484–2518. doi: 10.1021/acs.jnatprod.2c00487

Figure 15.

Figure 15.

Total biosynthesis of thermolides A–E (94–98). (A) Organization and predicted gene functions of the thm BGC. Black ORFs encode for enzymes involved in the biosynthesis of thermolides. (B) Proposed biosynthesis of thermolides.