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. 2022 Nov 1;125:195–208. doi: 10.1016/j.ijid.2022.10.035

Figure 8.

Figure 8

Different modulation of the memory T cell phenotype in CD4+ and CD8+ T cells and in the antigen-responding CD4+ T cells at T3 between patients with RA and HCWs.

T cell phenotype in HCWs (n = 15) and patients with RA (n = 30) characterized in total CD4+ (a) or CD8+ (b) T cells gated according to the expression of CD45RA and CCR7. Pie charts represent the distribution of CD4+ or CD8+ subpopulations (CD45RA+/−CCR7+/−) in HCWs or patients with RA. Colors reported in the graphs correspond to the single population represented in the wedges of the pies. (c) The frequency of CD45RA and CCR7 of antigen-responding CD4+ T cells was evaluated within HCWs (n = 13) and patients with RA (n = 15) responders. Pie charts represent the proportion of the CD45RA+/−CCR7+/− in HCWs or patients with RA. Statistical analysis was performed using Mann-Whitney U-test for graphs with a P-value <0.05 considered significant. Median is represented by red lines, and each dot represents a different HCW or patient with RA. Friedman test was used for pie charts to compare the frequencies within each group.

CD, cluster of differentiation; HCWs, health care workers; RA, rheumatoid arthritis; TCM, central memory; TEM, effector memory; TEMRA, terminally differentiated effector memory; Uns, unstimulated.