Table 3.
Longitudinal observation of the T cell and antibody responses.
| T1 | T2 | T3 | P-value | |||
|---|---|---|---|---|---|---|
| N (%) | 25 (100%) | 25 (100%) | 25 (100%) | |||
| Qualitative response | Antibody responders N (%) | HCWs | 25/25 (100%) | 25/25 (100%) | 25/25 (100%) | - |
| RA | 24/25 (96%) | 23/25 (92%) | 25/25 (100%) | 0.223a | ||
| T cell responders N (%) | HCWs | 25/25 (100%) | 25/25 (100%) | 25/25 (100%) | - | |
| RA | 17/25 (68%) | 17/25 (68%) | 18/25 (72%) | 0.819a | ||
| Quantitative response | Anti-RBD titersbinding antibody units/ml median (IQR) | HCWs | 3377 (1647-4839) | 178 (132-271) | 4608 (3040-6408) | <0.0001b |
| RA | 785 (458-1678) | 45 (19-94) | 1653 (969-3166) | <0.0001b | ||
| Spike interferon-γ levelspg/ml median (IQR) | HCWs | 262 (118-531) | 196 (66-490) | 525 (234-812) | 0.012b | |
| RA | 39.4 (5.3-177) | 70.6 (8.7-180) | 43.5 (14.5-168.5) | 0.961b |
Abbreviations: HCW, health care worker; IQR, interquartile range; N, number; RA, rheumatoid arthritis; RBD, receptor-binding domain.
a
Cochran's Q test; bFriedman test were performed for the statistical analysis.