Fig. 2.

A: Difference in days (median) between critical clinical events and disease phase assignment based on the individual trajectory-based approach (left) and the general time-of-infection-based approach (right). ICU: intensive care unit. B: Distribution of CRP and IL-6 values in different disease phases based on the individual trajectory-based (red) and general time-of-infection-based (blue) approach for disease phase assignment. C: Sum of earth mover's distance (EMD) from routine biochemical indices and proteomic levels comparing the trajectory-based (red) and time-of-infection-based (blue) approach for disease phase assignment. D: Length of disease phases (days; median) on patient level. E: Difference in days (median) between sampling time point and inflammation peak.