Table. Homologous and heterologous serum neutralizing antibody titers on days 27 and 56 after primary and secondary SARS-CoV-2 infection in hACE2K18 transgenic mice*.
| Primary infection, 102 TCID50 | Secondary infection, 104 TCID50 | Serum neutralizing antibodies (GMT) against indicated virus after primary and secondary infection |
||||
|---|---|---|---|---|---|---|
| BA.1 | BA.2† | BA.5† | Ancestral | Delta | ||
| BA.1 | BA.1 | 83/62 | 10/10 | 10/10 | 7‡/7‡ | 7‡/8‡ |
| Ancestral | BA.1 | 34‡/27‡ | 10/10 | 10/10 | 709/1,338 | 90‡/>440‡ |
| Delta | BA.1 | 16/60 | 10/35 | 10/53 | 55‡/124‡ | 129/>453 |
*Bold indicates homologous titers. GMT, geometric mean titer; TCID50, 50% tissue culture infectious dose. †Lower limit of detection in indicated assays is 10. In other assays, the lower limit of detection is 5. ‡Serum samples from different sets of 5 mice from the group were tested on days 27 and 56.