Table 3.
Each candidate senescence-targeting immunotherapeutics for improving age and age-related disorders
| Candidate target as surface protein |
Expression | Molecular action of therapeutic strategies | References |
|---|---|---|---|
| CD28 | human CD8+ T cell | Increase of CD28 by ectopic expression or other receptors associated with CD8+ T cell activation | Vicente et al., 2016 |
| CD44 | Senescent cells | Antibodies against CD44 directly induce the recruitment of monocytes to a senescent lesion site in senescent endothelial cells | Mun and Boo, 2010 |
| CD58/ICAM1 receptor | Senescent cells | Elimination of senescent cells by NK cells | Vicente et al., 2016 |
| CD26/dipeptidyl peptidase 4 (DPP4) | Replicative senescent fibroblasts | Elimination of senescent cells by NK cells | Kim et al., 2017 |
| Glycans or lipids | Senescent cells | Recognized by CD36, IgM on the surface of macrophages | Burton and Stolzing, 2018 |