Fig. 1.

TMAO increases AAA development in AngII-induced mouse models. A The serum TMAO level in TMAO-treated mice and in saline-treated mice. B Abdominal aorta after saline and TMAO treatment. C H&E micrographs from each group (scale bars = 500 µm). D–E AAA incidence (D) and analysis of maximal abdominal aortic diameters in each group (E). F The survival curve of mice after saline and TMAO treatment. G EVG staining in the suprarenal aorta after AngII or PBS treatment (scale bars, 500 µm, and 100 µm). H Analysis of elastin degradation scores from each group (n = 10 per PBS group and n = 20 per AngII group)