Table 1.

Echocardiographic assessment of morphometric cardiac parameters at baseline and in response to DEC therapy at 30, 90, and 180 days after systemic-intraosseous administration of DEC therapy into mdx/scid mice. Morphometric parameters: LVESD = left ventricular end systolic diameter, LVEDD = left ventricular end diastolic diameter, LVESV = left ventricular end systolic volume; LVEDV = left ventricular end diastolic volume; There were no significant differences observed in the morphometric parameters of DEC-treated versus vehicle injected control mice as assessed by M-mode measurements by VevoLab software. All data presented as mean ± SEM, non-parametric, unpaired Student's t-test were performed

Morphometric parameters
Experimental group/ Timepoint	LVESD (mm)	LVEDD (mm)	LVESV (μl)	LVEDV (μl)
Baseline
Vehicle (n = 4)	2.30 ± 0.54	3.36 ± 0.29	17.71 ± 7.33	46.80 ± 9.26
MBN/MBDMD1 × 106 (n = 4)	2.50 ± 0.3	3.53 ± 0.39	23.99 ± 8.47	53.27 ± 12.49
MBN/MBDMD5 × 106 (n = 4)	2.01 ± 0.38	3.03 ± 0.39	18.91 ± 10.55	42.33 ± 6.67
Day 30
Vehicle (n = 4)	2.25 ± 0.43	3.13 ± 0.47	18.88 ± 7.31	41.00 ± 12.60
MBN/MBDMD1 × 106 (n = 4)	2.62 ± 0.32	3.63 ± 0.37	25.84 ± 8.21	56.50 ± 13.65
MBN/MBDMD5 × 106 (n = 4)	2.66 ± 1.71	3.54 ± 2.69	10.84 ± 11.20	29.08 ± 16.71
Day 90
Vehicle (n = 4)	2.79 ± 0.27	3.86 ± 0.14	30.86 ± 6.96	65.26 ± 5.89
MBN/MBDMD1 × 106 (n = 4)	2.83 ± 0.17	3.93 ± 0.13	31.17 ± 4.29	67.95 + 5.49
MBN/MBDMD5 × 106 (n = 4)	2.30 ± 0.34	3.60 ± 0.27	19.39 ± 7.06	55.33 ± 10.11
Day 180
Vehicle (n = 4)	2.16 ± 0.28	3.36 ± 0.29	25.53 ± 6.04	53.69 ± 10.68
MBN/MBDMD1 × 106 (n = 4)	2.50 ± 0.34	3.53 ± 0.53	23.06 ± 6.85	53.45 ± 16.63
MBN/MBDMD5 × 106 (n = 4)	2.65 ± 0.28	3.92 ± 0.19	25.92 ± 7.00	69.61 ± 9.42