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. 2022 Aug 6;18(8):3083–3091. doi: 10.1007/s12015-022-10420-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Differentially expressed genes obtained from comprehensive transcriptome analysis. (A) Volcano plot of DEGs obtained by the Wald test using DESeq2 for the comparison of control and SB-treated cells. The x-axis represents the log base 2 of the gene expression ratio. The y-axis represents the negative log₁₀ of the adjusted q value. Red dots represent DEGs meeting the stringency cutoff; adjusted p value < 0.05 and |log₂ fold change|> 2. (B) Enrichment analysis of Gene Ontology Biological Processes using Cluster Profiler. Top 20 annotations are shown. The x-axis represents the number of gene clusters in each cluster label. The color represents the adjusted p values, and the size of the spots represents the gene number. (C) RT–qPCR for the representative DEGs enriched in SB-treated cells. The data are shown as the mean ± SEM (n = 6)