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. 2022 Jan 6;15(4):865–875. doi: 10.1007/s12265-021-10196-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Effects of FA on P21 expression and corresponding cyclins. FA may promote the increase of p21 expression through the promotion of NO production, and the increase of p21 expression affects the subsequent cell cycle-related proteins cyclin D-CDK4, cyclin E-CDK2 complex, and PCNA expression decline. The main statistical method used was Mann-Whitney U test after one-way ANOVA. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 vs. PDGF group