Table 6.
ALE data of subgroup analysis on GMV reduction in MwoA and MwA, CM, and EM.
| Brain region | Brodmann area | MNI coordinates | Cluster size (mm3) | P value (×10−2)* |
|---|---|---|---|---|
| MwoA vs HC | ||||
| R insula | BA 47 | 36, 20, −8 | 298 | .00255 |
| R anterior cingulate | BA 32 | 4, 24, −14 | 267 | .00662 |
| L postcentral gyrus | BA 40 | −36, −24, 48 | 212 | .00855 |
| R middle frontal gyrus | BA 11 | 22, 40, −20 | 149 | .00926 |
| MwA vs HC | ||||
| R posterior cerebellar lobe | 10, −82, −20 | 437 | .00069 | |
| L middle frontal gyrus | BA 6 | −26, 14, 52 | 319 | .00623 |
| L inferior frontal gyrus | BA 44 | −62, 12, 12 | 319 | .00623 |
| R cingulate gyrus | BA 32 | 2, 22, 44 | 305 | .00242 |
| R middle frontal gyrus | BA 9 | 40, 30, 24 | 305 | .01737 |
| L fusiform gyrus | BA 36 | −50, −42, −22 | 305 | .01737 |
| R insula | BA 13 | 48, −18, 2 | 305 | .00346 |
| L inferior temporal gyrus | BA 20 | −56, −16, −32 | 305 | .00346 |
| EM vs HC | ||||
| L precentral gyrus | BA 13 | −52, −10, 10 | 165 | .00555 |
| CM vs HC | ||||
| L uncus | BA 28 | −26, 8, −26 | 329 | .00087 × 10−2 |
| L parahippocampus | BA 34 | −20, 2, −18 | 277 | .00776 × 10−2 |
| R inferior frontal gyrus | BA 47 | 38, 28, −20 | 262 | .00925 × 10−2 |
| L precentral gyrus | BA 6 | −32, −12, 66 | 209 | .00043 |
ALE = activation likelihood estimation, BA = Brodmann area, CM = chronic migraine, EM = episodic migraine, GMV = gray matter volume, HC = healthy controls, L = left, MwA = migraine with aura, MwoA = migraine without aura, MNI = Montreal Neurological Institute, R = right.
*
Uncorrected P value < .003.