Table 1.

Description of the extension of the human genome epidemiology network’s Venice criteria to assess genetic main effect.

Criteria of consideration	Category	Proposed operationalization
Amount of evidence	A	Sample size over 1000
	B	Sample size 100-1000
	C	Sample size under 100
Replication	A	I2 < 50%
	B	25% < I2 < 50%
	C	I2 > 50%
Protection from bias	A	Consideration biases such as bias in genotyping, population stratification, and Selective reporting biases.
	B
		Bias in genotype definition = Not reported what was done/No quality control checks/Appropriate quality control checks.
	C
		Population stratification = Not reported what was done/Nothing done/Same descent group/Adjustment for reported descent/Family-based design/Genomic control, PCA or a similar method
		Selective reporting biases = Meta-analysis of published data/Retrospective efforts to include unpublished data/Meta-analysis within consortium.