Table 3.
Top 20 signaling pathways with related genes.
| Term | Pathway | Genes |
|---|---|---|
| hsa04066 | HIF-1 signaling pathway | NOS2, NOS3, INSR, BCL2, HMOX1, MTOR, VEGFA |
| hsa04020 | Calcium signaling pathway | CHRM2, NOS2, NOS3, ADRB1, DRD1, ADRB2, HTR2A, ADRA1A |
| hsa04080 | Neuroactive ligand-receptor interaction | CHRM2, ADRB1, DRD1, ADRB2, HTR2A, OPRM1, F2, NR3C1, ADRA1A |
| hsa05200 | Pathways in cancer | GSK3B, AR, JUN, MAPK8, NOS2, BCL2, PPARG, PTGS2, MTOR, VEGFA |
| hsa04726 | Serotonergic synapse | MAOB, MAOA, ALOX5, HTR2A, PTGS2, SLC6A4 |
| hsa00380 | Tryptophan metabolism | MAOB, MAOA, CYP1A2, CAT |
| hsa04915 | Estrogen signaling pathway | JUN, NOS3, OPRM1, ESR1, ESR2 |
| hsa05030 | Cocaine addiction | JUN, MAOB, MAOA, DRD1 |
| hsa00330 | Arginine and proline metabolism | MAOB, NOS2, MAOA, NOS3 |
| hsa04668 | TNF signaling pathway | JUN, MAPK8, VCAM1, PTGS2, SELE |
| hsa04931 | Insulin resistance | GSK3B, MAPK8, NOS3, INSR, MTOR |
| hsa04923 | Regulation of lipolysis in adipocytes | INSR, ADRB1, ADRB2, PTGS2 |
| hsa04024 | cAMP signaling pathway | CHRM2, JUN, MAPK8, ADRB1, DRD1, ADRB2 |
| hsa05210 | Colorectal cancer | GSK3B, JUN, MAPK8, BCL2 |
| hsa04728 | Dopaminergic synapse | GSK3B, MAPK8, MAOB, MAOA, DRD1 |
| hsa05031 | Amphetamine addiction | JUN, MAOB, MAOA, DRD1 |
| hsa00982 | Drug metabolism - cytochrome P450 | MAOB, MAOA, CYP1A2, CYP3A4 |
| hsa04261 | Adrenergic signaling in cardiomyocytes | BCL2, ADRB1, ADRB2, SCN5A, ADRA1A |
| hsa04917 | Prolactin signaling pathway | GSK3B, MAPK8, ESR1, ESR2 |