Table 3.
NAFLD related targets from metformin.
| Gene names | Entry | Protein names | Length (bp) |
|---|---|---|---|
| PLAU | P00749 | Urokinase-type plasminogen activator | 431 |
| ADORA1 | P30542 | Adenosine receptor A1 | 326 |
| METAP2 | P50579 | Methionine aminopeptidase 2 | 478 |
| CA1 | P00915 | Carbonic anhydrase 1 | 261 |
| TYMP | P19971 | Thymidine phosphorylase | 482 |
| VDR | P11473 | Vitamin D3 receptor | 427 |
| FGR | P09769 | Tyrosine-protein kinase | 529 |
| RPS6KA5 | O75582 | Ribosomal protein S6 kinase alpha-5 | 802 |
| ACACA | Q13085 | Acetyl-CoA carboxylase 1 | 2346 |
| IKBKB | O14920 | Inhibitor of nuclear factor kappa-B kinase | 756 |
| PIK3CA | P42336 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1068 |
| NR4A1 | P22736 | Nuclear receptor subfamily 4 group A member 1 | 598 |
| DPP9 | Q86TI2 | Dipeptidyl peptidase 9 | 863 |
| HIF1A | Q16665 | Hypoxia-inducible factor 1-alpha | 826 |
| NFE2L2 | Q16236 | Nuclear factor erythroid 2-related factor 2 | 605 |
| NR3C1 | P04150 | Glucocorticoid receptor | 777 |
| SIRT3 | Q9NTG7 | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 399 |
| AURKB | Q96GD4 | Aurora kinase B | 344 |
| GLS | O94925 | Glutaminase kidney isoform, mitochondrial | 669 |
| MAP4K2 | Q12851 | Mitogen-activated protein kinase kinase kinase kinase 2 | 820 |
| CCR2 | P41597 | C-C chemokine receptor type 2 | 374 |
| PIK3R1 | P27986 | Phosphatidylinositol 3-kinase regulatory subunit alpha | 724 |
| NFKB1 | P19838 | Nuclear factor NF-kappa-B p105 subunit | 968 |
| SIRT1 | Q96EB6 | NAD-dependent protein deacetylase sirtuin-1 | 747 |
| TDO2 | P48775 | Tryptophan 2,3-dioxygenase | 406 |
| NR1I2 | O75469 | Nuclear receptor subfamily 1 group I member 2 | 434 |
| APEX1 | P27695 | DNA-(apurinic or apyrimidinic site) endonuclease | 318 |
| CYP3A4 | P08684 | Cytochrome P450 | 503 |
| RPS6KB1 | P23443 | Ribosomal protein S6 kinase beta-1 | 525 |
| NOS2 | P35228 | Nitric oxide synthase, inducible | 1153 |
| NOS1 | P29475 | Nitric oxide synthase, brain | 1434 |
| SLC47A1 | Q96FL8 | Multidrug and toxin extrusion protein 1 | 570 |
| NOS3 | P29474 | Nitric oxide synthase, endothelial | 1203 |
| INMT | O95050 | Indolethylamine N-methyltransferase | 263 |
| SLC22A1 | O15245 | Solute carrier family 22 member 1 | 554 |
| HRH2 | P25021 | Histamine H2 receptor | 359 |
| ESR2 | Q92731 | Estrogen receptor beta | 530 |
| ACHE | P22303 | Acetylcholinesterase | 614 |
NAFLD = nonalcoholic fatty liver disease.