Table 1.
List of exosomal formulations undergoing clinical trials aimed at diagnosis and treatment of cancer.
| Clinical Trial ID | Description | Duration | Cancer type | Sponsor/Agency |
|---|---|---|---|---|
| NCT01779583 | Circulating exosomes as prognostic and predictive biomarker in advanced gastric cancer patient | 2013–2016 | Gastric | Hospital Miguel Servet |
| NCT02393703 | Interrogation of Exosome-mediated Intercellular Signaling in Patients with Pancreatic Cancer | 2015–2019 | Pancreatic | Memorial Sloan Kettering Cancer Center |
| NCT01668849 | Edible plant-derived exosome ability to prevent oral Mucositis associated with chemoradiation treatment of head and neck cancer | 2012–2018 | Head and neck | James Graham Brown Cancer Centre |
| NCT01294072 | Study investigating the ability of plant exosome to deliver curcumin to normal and colon cancer tissue | 2011–2020 | Colon | James Graham Brown Cancer Centre |
| NCT02071719 | Predicting response to kinase inhibitors based on protein phosphorylation profiles in tumor tissue from advanced renal cell cancer patients | 2012–2017 | Renal cell | VU University Medical Center |
| NCT01550523 |
Pilot Immunotherapy trial for recurrent malignant gliomas IGF-1R/AS ODN |
2012–2013 | Malignant glioma of brain | Thomas Jefferson University |
| NCT02454930 | Evaluation of microRNA expression in blood and cytology for detecting Barrett’s Esophagus and associated neoplasia | 2015–2018 | Esophageal adenocarcinoma | Midwest Biomedical Research Foundation |
| NCT02310451 | Study of molecular mechanism implicated in the pathogenesis of melanoma | 2014–2016 | Metastatic melanoma | Center HospitalierUniversitaire de Nice |
| NCT02147418 | Exosome testing as a screening modality for human Papilloma-positive Oropharyngeal Squamous Cell Carcinoma | 2015–2019 | Oropharyngeal | New Mexico Cancer Care Alliance |
| NCT03542253 | Combined Diagnosis of CT and Exosome in Early Lung Cancer | 2018–2019 | Lung | Second Affiliated Hospital of Soochow University |
| NCT03317080 | Dynamic Monitoring Circulating Tumor DNA in Surgical Patients with Lung Cancer | 2017–2023 | Lung | West China Hospital |
Details obtained from https://clinicaltrials.gov/.