Table 3.
Marketed anticancer formulations of liposomes.
| Trade name | Drug | Lipid component | Company | Approval year | Cancer |
|---|---|---|---|---|---|
| Doxil | Doxorubicin | HSPC:Cholesterol:PEG 2000-DSPE, stealth liposome |
Johnson and Johnson, Baxter Healthcare Dr. Reddy’s Lab Ltd |
FDA 1995 (USA) FDA 1999 (USA) EU 2000 |
Kaposi’ sarcoma Refractory ovarian CA Refractory Breast CA |
| LipoDox | Doxorubicin | DSPC:Cholesterol:DSPE-PEG stealth liposome | Sun Pharma Global FZE | FDA 2013 | Kaposi’ sarcoma |
| Myocet | Doxorubicin | EPC: Cholesterol |
Ban Corporation, Sepherion Therapeutics |
EU 2000, Canadian approval 2001, one | Metastatic breast cancer |
| DaunoXome | Daunorubicin | DSPC: Cholesterol:PEG stealth liposome | NeXstar Pharmaceuticals, Inc., CO, Gilead Science, UK | On the market since 1996 (USA and Europe) | Refractory Kaposi’ sarcoma |
| Marqibo | Vincristine | Egg Sphingomyelin: cholesterol | Talon Therapeutics | FDA 2012 | Acute Lymphoblastic leukemia |
| Onco TCS | Vincristine | Sphingomyelin: cholesterol | Inex pharmaceuticals | Phase II/IIIclinical trials | Refractory non-Hodgkin’s lymphoma |
| DepoCyt | Cytarabine |
DOPC:DPPG: Cholesterol:Triolein Multivesicular liposome |
Depo Tech, Enzon Pharmaceuticals, Pacira Pharmaceuticals | FDA 1999, 2007 | Malignant lymphomatous meningitis |
| Onivyde | Irinotecan | DSPC:Cholesterol:DSPE-PEG | Ipsen Biopharmaceuticals | FDA 1996 | Pancreatic adenocarcinoma |
| Caelyx | PC-PEG-methoxy polyethylene glycol | Johnson and Johnson, | EU 1996 | Metastatic breast cancer | |
| Mepact | Mifamurtide | Muramyl tripeptide-PE | Takeda France SAS | EU 2009 | Non-metastatic Osteosarcoma |
| CPX-351 (Vyxeos) | Daunorubicin; Cytarabine | DSPC: DSPG: Cholesterol | Jazz Pharmaceuticals | FDA 2017 | Acute myeloid leukemia |
| Lipusu | Paclitaxel | PC:Cholesterol | Luye Pharmaceutical Co. Ltd. |
China 2003 FDA 2005 |
Gastric, ovarian and lung cancer |
Reproduced from Madamsetty et al. [144]. 10.1016/C2019-0-02790-2 Copyright © 2021 Elsevier Inc. In Press.
DSPE distearoylphosphatidyl ethanolamine, DSPC distearoylphosphatidylcholine, DOPC dioleoyl-sn-glycero-3-phosphocholine, DPPG dipalmitoyl-sn-glycero-3-phosphoglycerol, PC phosphatidylcholine, HSPC hydrogenated soy phosphatidylcholine, EPC egg phosphatidylcholine, PEG polyethylene glycol.