Table 1.
Significantly differential kidney tissue metabolites, relative intensities, fold changes (FC), P values and types between the sham group and UUO group at 1, 2 and 3 weeks.
| Sham | UUO_1W | UUO_2W | UUO_3W | UUO_1W vs Sham | UUO_2W vs Sham | UUO_3W vs Sham | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Metabolites | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | FCa | Pb | FCa | Pb | FCa | Pb | Trend downc | Trend upc | Types |
| 1-Methoxypyrene | 1.23 ± 0.6 | 18.21 ± 2.1 | 21.60 ± 4.0 | 28.22 ± 5.8 | 14.8 | 2.7 × 10−12 | 17.5 | 1.2 × 10−9 | 22.9 | 3.1 × 10−9 | −1 | −1 | PHA |
| Indoxyl sulfate | 2.48 ± 1.0 | 21.60 ± 6.5 | 30.19 ± 3.4 | 36.97 ± 4.9 | 8.7 | 9.2 × 10−7 | 12.1 | 2.5 × 10−12 | 14.9 | 1.6 × 10−11 | −1 | −1 | Indole |
| 6-Hydroxymelatonin | 3.98 ± 1.5 | 19.25 ± 5.5 | 24.16 ± 6.8 | 27.82 ± 8.0 | 4.8 | 2.4 × 10−6 | 6.1 | 9.8 × 10−7 | 7.0 | 9.4 × 10−7 | −1 | −1 | Indole |
| 5-Methoxytryptamine | 3.27 ± 1.6 | 13.79 ± 3.1 | 20.64 ± 4.6 | 26.02 ± 4.7 | 4.2 | 5.4 × 10−7 | 6.3 | 8.8 × 10−8 | 7.9 | 3.3 × 10−9 | −1 | −1 | Indole |
| Benzatropine | 41.19 ± 6.1 | 59.39 ± 9.8 | 90.99 ± 7.1 | 97.58 ± 17.6 | 1.4 | 9.5 × 10−4 | 2.2 | 1.2 × 10−9 | 2.4 | 1.4 × 10−6 | 1 | −1 | OBR |
| m-Chlorohippuric acid | 78.39 ± 45.6 | 176.2 ± 37.1 | 184.49 ± 34.2 | 164.51 ± 41.3 | 2.2 | 6.0 × 10−4 | 2.4 | 2.2 × 10−4 | 2.1 | 2.4 × 10−3 | −1 | −1 | OBR |
| Phenbenzamine | 44.28 ± 16.3 | 70 ± 10.7 | 70.7 ± 5.6 | 82.62 ± 23.6 | 1.6 | 3.6 × 10−3 | 1.6 | 1.2 × 10−3 | 1.9 | 3.3 × 10−3 | 1 | −1 | OBR |
| Phenylacetaldehyde | 2.54 ± 1.5 | 7.59 ± 2.0 | 7.16 ± 2.7 | 10.11 ± 6.9 | 3.0 | 1.1 × 10−4 | 2.8 | 1.6 × 10−3 | 4.0 | 1.3 × 10−2 | −1 | −1 | OBR |
| Phenyl glucuronide | 12.69 ± 3.0 | 16.75 ± 4.0 | 19.95 ± 4.0 | 27.23 ± 10.3 | 1.3 | 4.9 × 10−2 | 1.6 | 1.8 × 10−3 | 2.1 | 3.1 × 10−3 | 1 | −1 | OBR |
| (+)-Aspidospermidine | 156.81 ± 153.3 | 369.08 ± 18.6 | 364.35 ± 37.4 | 398.36 ± 58.7 | 2.4 | 2.7 × 10−3 | 2.3 | 3.7 × 10−3 | 2.5 | 1.6 × 10−3 | −1 | −1 | OBR |
| p-Cresyl sulfate | 366.07 ± 103.1 | 561.24 ± 46.2 | 513.86 ± 47.6 | 484.86 ± 86.7 | 1.5 | 4.4 × 10−4 | 1.4 | 3.9 × 10−3 | 1.3 | 3.5 × 10−2 | −1 | −1 | OBR |
| L-Formylkynurenine | 86.28 ± 19 | 110.1 ± 20.3 | 116.36 ± 16.1 | 169.53 ± 45.3 | 1.3 | 4.0 × 10−2 | 1.3 | 6.5 × 10−3 | 2.0 | 5.1 × 10−4 | 1 | −1 | OBR |
| Suprofen S-oxide | 111.8 ± 17.1 | 136.22 ± 19.7 | 141.27 ± 18.3 | 153.39 ± 20.3 | 1.2 | 2.6 × 10−2 | 1.3 | 7.6 × 10−3 | 1.4 | 9.7 × 10−4 | 1 | −1 | OBR |
| 3-Hydroxyhippuric acid | 10.48 ± 4.5 | 18.46 ± 7.6 | 17.09 ± 4.5 | 17.1 ± 3.9 | 1.8 | 3.1 × 10−2 | 1.6 | 1.5 × 10−2 | 1.6 | 1.0 × 10−2 | −1 | −1 | OBR |
| Xanthurenic acid | 49.1 ± 19.7 | 70.8 ± 16.1 | 79.9 ± 28.0 | 87.58 ± 33.3 | 1.4 | 4.0 × 10−2 | 1.6 | 3.2 × 10−2 | 1.8 | 2.0 × 10−2 | 1 | −1 | OBR |
| Pentosidine | 15.38 ± 8.3 | 28.96 ± 10.4 | 26.47 ± 10.5 | 37.74 ± 7.8 | 1.9 | 1.7 × 10−2 | 1.7 | 4.6 × 10−2 | 2.5 | 1.4 × 10−4 | −1 | −1 | OBR |
aFC was calculated on the basis of mean ratios for UUO_1W vs sham, UUO_2W vs sham, or UUO_3W vs sham. FC with a value >1 indicates a higher intensity of the metabolites in different UUO group compared to sham group, whereas a FC value <−1 indicates a lower intensity of the metabolites in different UUO group compared to sham group.
bP values are calculated from a one-way ANOVA.
cDecreased levels for progressive renal injury: 1, increased levels for progressive renal injury: −1.