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. 2022 Apr 14;43(11):2956–2966. doi: 10.1038/s41401-022-00905-7

Fig. 7. TST and osimertinib decrease the expression levels of c-FLIP and FoxM1.

Fig. 7

a A549 and H157 cells were treated with the indicated concentrations of TST. Twenty-four hours after treatment, cell lysates were subjected to immunoblotting. b A549 and H157 cells were treated with TST as indicated. Immunoblot analysis was performed. c A549 cells were transfected with the c-FLIP plasmid for 24 h and were then treated with TST at the indicated concentrations. The protein expression of FoxM1 and c-FLIP was measured by Western blotting after 24 h of treatment. d, e A549 and H157 cells were treated with TST as indicated. The mRNA levels of FoxM1 and c-FLIP were determined by qRT-PCR. f H157 and HCC827 cells were exposed to different concentrations of osimertinib, and the indicated proteins were analyzed by Western blotting. The data are presented as the mean ± SD of triplicate analyses. *P < 0.05 and **P < 0.01.