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. 2022 Apr 14;43(11):2956–2966. doi: 10.1038/s41401-022-00905-7

Fig. 8. Schematic diagram of the proposed model.

Fig. 8

a c-FLIP binds to FoxM1 to prevent FoxM1 protein degradation mediated by ubiquitin-proteasome pathway. c-FLIP enhances the FoxM1/p65/β-catenin positive feedback loop by upregulating FoxM1 and p65 to further increase FoxM1 expression. b TST and osimertinib decrease c-FLIP and FoxM1 expression to inhibit lung cancer growth.