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. 2022 May 17;43(11):2977–2992. doi: 10.1038/s41401-022-00917-3

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© The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society 2022, corrected publication 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 1 — a There is higher APOC1 expression in GBM than that in normal tissues. APOC1 expression in tumor and normal tissues was analyzed in website (http://gepia.cancer-pku.cn/). b Expression of APOC1 is higher in GBM than normal tissues. Expression of APOC1 in tumor and normal tissues was analyzed in website (http://gdac.broadinstitute.org/). c APOC1 expression is high in GBM patients. Data of APOC1 expression in normal and GBM patients from TCGA database were analyzed in website (http://ualcan.path.uab.edu/analysis.html). d APOC1 is highly expressed in GBM. APOC1 expression between normal and GBM patients was analyzed in website (https://www.oncomine.org/). e Patients with high APOC1 expression have lower survival rates. Survival rate of GBM patients with high APOC1 expression and low APOC1 expression was analyzed in website (https://www.betastasis.com/). f APOC1 was highly expressed in GBM tissues than adjacent normal tissues. Western blotting analysis of APOC1 expression in GBM patients (n = 10). g Quantitative analysis of APOC1 expression in the GBM tissues and adjacent brain tissues. Bars indicates SD, P values represented the significant difference between GBM tissues and adjacent brain tissues, Student’s t test. h Immunohistochemical analysis of APOC1 expression in 37 glioma patient tissues and 13 adjacent normal tissues. Representative images showing the APOC1 protein in normal tissue and glioma tissue. Scale bar = 100 μm. i Quantitative analysis of APOC1 expression in the 37 glioma tissues and 13 normal tissues. Bars indicates SD, P values represented the significant difference between normal tissues and GBM tissues, Student’s t test.