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. 2022 May 17;43(11):2977–2992. doi: 10.1038/s41401-022-00917-3

Fig. 2. APOC1 improved proliferation, migration, invasion, and colony formation of GBM cells.

Fig. 2

a APOC1 expression in normal glial cells (HEB and HA1800) and GBM cells (U251, U138, A172 and U87). b Overexpression of APOC1 increased proliferation of U251 cells in 24, 48, and 72 h. c Knockdown of APOC1 inhibited proliferation of U87 cells in 24, 48, and 72 h. d Overexpression of APOC1 improved the migration and invasion of U251-APOC1 cells. Scale bar = 100 μm. e Knockdown of APOC1 inhibited the migration and invasion ability of U87-siAPOC1 cells. Scale bar = 100 μm. f Overexpression of APOC1 improved the colony formation of U251-APOC1 cells whereas knockdown of APOC1 inhibited colony formation of U87-siAPOC1 cells. g 3D matrigel assay showed overexpression of APOC1 promoted growth of U251-APOC1 cells whereas knockdown of APOC1 inhibited growth of U87-siAPOC1 cells in 3D Matrigel. Scale bar = 100 μm. Experiments were performed in triplicate. Data are presented as mean ± SD (n = 3). Statistical significance was determined by Student’s t test or one-way ANOVA, ***P < 0.001 vs. NC.