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. 2022 May 17;43(11):2977–2992. doi: 10.1038/s41401-022-00917-3

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© The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society 2022, corrected publication 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 9 — APOC1 reduced the sensitivity of GBM cells to ferroptosis by up-regulating the KEAP1/NRF2/HO-1 and NQO1 pathway and the CBS/GPX4 axis, which finally decreasing intracellular ROS and Fe²⁺ level.