Fig. 1. CZL80 rescues progressive motor dysfunction in photothrombotic mice.

a The chemical structure of CZL80. b Diagram showing the experimental design in this figure. CZL80 (10 or 30 mg·kg⁻¹·d⁻¹) or vehicle was intraperitoneally injected daily during Day1-7 after photothrombosis (PT), and the motor function was measured daily. c Foot fault of left forelimb in the grid-walking task and (d) Forelimb asymmetry in the cylinder task. All results were presented as means ± SEM (n = 9 per group). Statistical significance was determined by using one-way ANOVA with Tukey’s post hoc test, ^*P < 0.05, ^**P < 0.01 and ^***P < 0.001 vs. PT. e Representative immunoblots showing the expression of Caspase-1 and IL-1β in the peri-infarct cortex of mice at indicated time points after PT. f Representative immunoblots showing the expression level of Caspase-1 with or without CZL80 in the peri-infarct cortex of mice on Day7 after PT.