Table 4.

Cox proportional hazards model for Grade ≥2 CRS in lymphoma cohort.

Variable	Univariate analysisa				Multivariate analysis
	HR	Lower 95% CI	Upper 95% CI	P value*	HR	Lower 95% CI	Upper 95% CI	P value*
Age at CAR Tb	1.002	0.986	1.018	0.8
Sex (male)	0.76	0.49	1.16	0.2
CAR T construct (axi-cel)	4.67	1.71	12.75	<0.01*	3.48	1.12	10.84	0.03*
ECOG ≥ 1	1.40	0.91	2.15	0.1
Lines of therapy prior to CAR Tb	0.908	0.780	1.056	0.2
Bridging therapy prior to CAR T	0.64	0.41	1.03	0.06	0.75	0.45	1.25	0.3
Time from diagnosis to CAR T (months)b	0.999	0.995	1.004	0.7
ANCb	1.049	0.992	1.109	0.09	1.017	0.955	1.083	0.6
Hemoglobinb	0.945	0.845	1.058	0.3
Plateletsb	1.003	1.000	1.005	0.03*	1.002	1.000	1.004	0.04*
LDHb	1.001	1.000	1.002	0.01*	1.002	1.001	1.002	<0.01*
Albuminb	0.709	0.462	1.089	0.1
Prophylactic G-CSFc	3.31	1.75	6.24	<0.01*	2.15	1.11	4.18	0.02*

*P < 0.05, indicating statistical significance in univariate or multivariate models, is denoted by asterisks.

^aVariables with P < 0.10 in Cox univariate proportional hazards model were included in the multivariate model.

^bContinuous hazard ratio (per unit change in regressor).

^cProphylactic G-CSF refers to exposure to G-CSF prior to CAR T cell infusion.