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. 2022 Oct 18;13:1003970. doi: 10.3389/fimmu.2022.1003970

Figure 1.

Figure 1

The outline of skin architecture with main points of anatomical contact between the epidermis, the immune and the neuronal networks. Three main skin compartments are shown: the stratified epidermis; representative cellular components of innate and adaptive immunity; the nervous system, with afferent endings in close contact with Langerhans cells (LCs) in the epidermis, as well as dermal DC and mast cells in the dermis. Created with BioRender.com.