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Schematic representation of the pathways involved in neutrophil infiltration in CRCLM. RUNX1 is highly expressed in the cancer cells of vessel co-opting CRCLM lesions compared to angiogenic lesions, which induces the expression of TGFβ1 and Ang1 in the neighbouring liver parenchyma. The overexpression of Ang1 incites the migration of neutrophils into the tumour microenvironment.
