Table 4. Multiple Linear Regression Analyses of the Relationships Between NID and Variables.
| NID | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variables | Total | Subjects without ARBs/ACEIs/ Diuretics/MRAs | Subjects with ARBs/ACEIs/ Diuretics/MRAs | ||||||||||||
| β | VIF | Standard error | t value | P value | β | VIF | Standard error | t value | P value | β | VIF | Standard error | t value | P value | |
| Potassium, mmol/L | 0.098 | 1.14 | 0.375 | 3.82 | ＜0.001 | 0.083 | 1.19 | 0.555 | 2.23 | 0.03 | 0.121 | 1.15 | 0.516 | 3.21 | 0.001 |
| Age, yr | -0.211 | 2.00 | 0.012 | -6.19 | ＜0.001 | -0.159 | 2.34 | 0.017 | -3.04 | 0.002 | -0.196 | 1.37 | 0.021 | -4.75 | ＜0.001 |
| Men | 0.045 | 1.31 | 0.165 | 1.64 | 0.10 | 0.028 | 1.54 | 0.260 | 0.67 | 0.51 | 0.080 | 1.25 | 0.220 | 2.03 | 0.04 |
| Body mass index, kg/m2 | -0.048 | 1.34 | 0.043 | -1.73 | 0.08 | -0.057 | 1.32 | 0.067 | -1.44 | 0.15 | -0.035 | 1.29 | 0.057 | -0.88 | 0.38 |
| Systolic blood pressure, mm Hg | -0.066 | 1.14 | 0.008 | -2.57 | 0.01 | -0.078 | 1.30 | 0.012 | -2.00 | 0.04 | -0.042 | 1.11 | 0.011 | -1.14 | 0.25 |
| Heart rate, bpm | 0.038 | 1.11 | 0.013 | 1.51 | 0.13 | -0.008 | 1.19 | 0.018 | -0.22 | 0.83 | 0.085 | 1.11 | 0.018 | 2.29 | 0.02 |
| Triglycerides, mmol/L | -0.009 | 1.20 | 0.119 | -0.34 | 0.73 | -0.063 | 1.17 | 0.156 | -1.71 | 0.09 | 0.061 | 1.29 | 0.189 | 1.52 | 0.13 |
| HDL cholesterol, mmol/L | 0.015 | 1.28 | 0.363 | 0.54 | 0.59 | 0.002 | 1.27 | 0.510 | 0.05 | 0.96 | 0.034 | 1.29 | 0.519 | 0.84 | 0.40 |
| Glucose, mmol/L | -0.016 | 1.32 | 0.075 | -0.59 | 0.55 | -0.032 | 1.28 | 0.107 | -0.84 | 0.40 | -0.019 | 1.43 | 0.107 | -0.46 | 0.64 |
| eGFR, ml/min/1.73 m2 | 0.065 | 1.63 | 0.009 | 2.13 | 0.03 | 0.119 | 1.57 | 0.014 | 2.80 | 0.005 | 0.004 | 1.32 | 0.013 | 0.10 | 0.92 |
| Sodium, mmol/L | 0.005 | 1.18 | 0.056 | 0.19 | 0.85 | -0.012 | 1.20 | 0.084 | -0.31 | 0.76 | 0.027 | 1.25 | 0.077 | 0.69 | 0.49 |
| Current smoking | -0.020 | 1.23 | 0.196 | -0.76 | 0.45 | -0.008 | 1.29 | 0.257 | -0.22 | 0.83 | -0.022 | 1.16 | 0.322 | -0.57 | 0.57 |
| Cardiovascular disease | -0.066 | 1.45 | 0.216 | -2.26 | 0.02 | -0.067 | 1.29 | 0.363 | -1.73 | 0.08 | -0.068 | 1.59 | 0.275 | -1.53 | 0.13 |
| ARBs/ACEIs | -0.021 | 1.43 | 0.167 | -0.72 | 0.47 | ||||||||||
| Diuretics | 0.020 | 1.21 | 0.225 | 0.76 | 0.45 | ||||||||||
| MRAs | -0.007 | 1.21 | 0.371 | -0.27 | 0.78 | ||||||||||
| Calcium channel blockers | -0.157 | 1.37 | 0.163 | -5.57 | ＜0.001 | -0.129 | 1.45 | 0.262 | -3.14 | 0.002 | -0.166 | 1.14 | 0.211 | -4.41 | ＜0.001 |
| β-blockers | 0.063 | 1.29 | 0.235 | 2.31 | 0.02 | 0.006 | 1.12 | 0.444 | 0.18 | 0.86 | 0.108 | 1.34 | 0.277 | 2.66 | 0.008 |
| Lipid-lowering drugs | -0.014 | 1.50 | 0.173 | -0.49 | 0.62 | -0.011 | 1.61 | 0.287 | -0.26 | 0.79 | -0.028 | 1.30 | 0.218 | -0.69 | 0.49 |
| Hypoglycemic drugs | -0.018 | 1.33 | 0.195 | -0.66 | 0.51 | -0.037 | 1.29 | 0.325 | -0.97 | 0.33 | -0.010 | 1.38 | 0.249 | -0.24 | 0.81 |
The adjusted r2 of the model for NID in all subjects was 0.17.
The adjusted r2 of the model for NID in subjects without ARBs/ACEIs/Diuretics/MRAs was 0.17. The adjusted r2 of the model for NID in subjects with ARBs/ACEIs/Diuretics/MRAs was 0.11.
NID indicates nitroglycerine-induced vasodilation; ARB, angiotensin receptor blocker; ACEI, angiotensin-converting enzyme inhibitor; MRA, mineralocorticoid receptor antagonist; VIF, variance inflation factor; HDL, high-density lipoprotein; LDL, low-density lipoprotein; eGFR, estimated glomerular filtration rate.