. 2001 Nov;8(6):1097–1103. doi: 10.1128/CDLI.8.6.1097-1103.2001

TABLE 3.

Significant correlations between serum cytokine levels and matching intracellular cytokines^a

Cytokine	Cell type	Stimulation status^b	Coefficient	P	Test^c	No. of patients assessed
IL-2	None	NA^d	NA	NA	NA	44
IL-4	NA	NA	NA	NA	NA	0
IL-6	CD3⁺ CD8⁺ cells	U	+0.36	<.001	P	82
	CD3⁺ CD8⁺ cells	S	+0.26	0.017	P	82
IL-8	Lymphocytes	U	+0.21	0.017	Sp	128
	CD3⁺ cells	U	+0.22	0.012	Sp	128
	CD3⁺ CD8⁺ cells	U	+0.33	<.001	Sp	128
	Monocytes	U	+0.30	<.001	Sp	128
	CD3⁺ cells	S	+0.23	0.009	Sp	127
	CD3⁺ CD8⁺ cells	S	+0.39	<.001	Sp	127
IL-10	Lymphocytes	S	+0.30	0.018	Sp	61
IFN-γ	Lymphocytes	U	+0.30	0.003	P	95
	CD3⁺ cells	U	+0.35	<.001	Sp	95
	CD3⁺ CD8⁺ cells	S	+0.25	0.020	P	85
	CD3⁺ CD8⁻ cells	S	+0.25	0.020	P	85
TNF-α	None	NA	NA	NA	NA	29

Correlations between percentages of cells making cytokine and serum cytokine levels, including only those with detectable titers. Listed only if trend remained with outliers excluded. All values for serum IL-4 levels were nondetectable (<15.6 pg/ml); therefore, trends could not be assessed.

Unstimulated cells (U) and cells stimulated with PMA and ionomycin (S) (both with brefeldin A).

Abbreviations: P, Pearson; Sp, Spearman.

NA, nonapplicable.