Skip to main content
. 2022 Jul 6;28(21):4702–4713. doi: 10.1158/1078-0432.CCR-22-1115

Figure 1.

Figure 1. The spectrum of RB1 genomic alterations and Rb protein expression profiles in SCLC. A, Grouping of SCLC (n = 208) according to Rb immunoexpression and the presence of RB1 genomic alterations. *, detected by manual review only. mut, mutated; wt, wild type; exp, expressed. B, Contingency table summarizing the total rates of subgroups based on RB1 mutations and Rb expression for alterations detected by routine clinical pipeline (left) and full set of alterations after manual review (right). C, Pie charts with the distribution of RB1 mutation types detected in the entire cohort (left) and those associated with Rb expression (right). D, Genomic mapping of selected RB1 mutations (nonsense, frameshift, splicing, missense, and in-frame variants). *, associated with Rb expression.

The spectrum of RB1 genomic alterations and Rb protein expression profiles in SCLC. A, Grouping of SCLC (n = 208) according to Rb immunoexpression and the presence of RB1 genomic alterations. *, Detected by manual review only. mut, mutated; wt, wild type; exp, expressed. B, Contingency table summarizing the total rates of subgroups based on RB1 mutations and Rb expression for alterations detected by routine clinical pipeline (left) and full set of alterations after manual review (right). C, Pie charts with the distribution of RB1 mutation types detected in the entire cohort (left) and those associated with Rb expression (right). D, Genomic mapping of selected RB1 mutations (nonsense, frameshift, splicing, missense, and in-frame variants). *, Associated with Rb expression.