Table 2.

The evidence of CircRNA roles in ischemic stroke via autophagy regulation.

Cell line/treatment	Animal/Disease model	Sample	DE CircRNA and expression		Regulating axis	Autophagy flux	Apoptosis activation	DE CircRNA's Roles in IS	References
Evidences from basic research
Primary mouse astrocyte,	Male C57BL/6J mouse	Astrocytes	circHECTD1	Up	circHECTD1/MIR142/	Upregulated	Undefined	Detrimental	(25)
A172 cell					TIPARP/Beclin1	The nucleation of autophagy
OGD-R	tMCAO
Primary astrocyte	Male C57BL/6J mice	Astrocytes	circSHOC2	Up	circSHOC2/miR-7670-3p/SIRT1/Beclin1	Downregulated	Decreased	Protective	(24)
						The nucleation of autophagy
OGD	MCAO
A172 and SK-N-AS	Male Sprague Dawley rats	Astrocytes	circ_0025984	Down	circ_0025984/miR-143-3p/TET1//ORP150/GRP78/ATG7	Upregulated	Increased	Protective	(22)
OGD	MCAO					The elongation of autophagy
BEnd.3 or HBMEC	C57BL/6J mice	BMECs	circ-FoxO3	Up	circ-FoxO3/mTOR/mTORC1	Upregulated	Undefined	Protective	(23)
					circ-FoxO3/E2F1/PEKFB3/	The initiation of autophagy
OGD/R	MCAO/R
HT22 cells	Male C57BL/6J mice	Neurons	circ_016719	Up	circ_016719/miR-29c/Map2k6/	Upregulated	Increased	Detrimental	(26)
					Beclin1	The nucleation of autophagy
OGD/R	tMCAO
Primary astrocyte	C57BL/6 mice	Astrocytes	circAkap7	Down	circAkap7/miR-155-5p/ATG12, NRF2	Downregulated	Increased	Protective	(27)
OGD/R	tMCAO					The elongation of autophagy