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. 2022 Oct 18;13:1013686. doi: 10.3389/fimmu.2022.1013686

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Copyright © 2022 Zhou, Yu, Yan, Liang, Ma, Long, Du, Mao and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Safety evaluation of lactate. (A) The cytotoxicity results determined by the CCK8 assay (n=3). (B) Lactate was added to the cell culture media. pH was measured over 2 hours. (C) Effects of lactate on body weight in normal mice (N=6). (D) Effect of exogenous lactic acid on serum lactic acid in normal mice (n=3). (E) Effect of lactate on organs of normal mice (n=3).