Figure 2.

Pathways involved in JIMT-1 trastuzumab resistance (log₂ FC normalized to SKBR3 signals). AFISimilarly expressed protein: light grey; antibody not available/poor performance: no fill; overexpressed total protein ≥ 1.5-fold (log₂ FC ≥ 0.58): light orange; ≥ 2-fold: *; under-expressed total protein ≤0.67 (log₂ FC ≤ -0.58): light green; ≤ 0.5-fold: *; overexpressed phosphosite ≥ 1.5-fold: orange; ≥ 2-fold: *; underexpressed phosphosite ≤ 0.67: green; ≤ 0.5-fold: *; predicted active protein: dark red outline; predicted inactive protein: dark blue outline.