. 2022 Oct 31;5(10):e2238569. doi: 10.1001/jamanetworkopen.2022.38569

Table 2. Interval From First Consultation With Red-Flag Symptom or Sign to Cancer Diagnosis (n = 2115).

Patient group	Interval, d			Multivariable quantile regression
	Median (50th centile)	IQR		50th centile		75th centile
	Median (50th centile)	25th Centile	75th Centile	Adjusted interval (95% CI)	P value	Adjusted interval (95% CI)	P value
MHM
No	133	47	422	Reference^a	NA	Reference^a	NA
Yes	326	75	552	224.4 (159.1-289.8)	.003	466.5 (413.4-519.6)	<.001
Age group, y
<45	196	56	454	230.6 (157.0-304.1)	.005	468.5 (319.2-617.8)	.18
45-54	110	37	356	126.7 (94.1-159.4)	.97	351.5 (282.7-420.3)	.69
55-64	100	39	342	Reference^a	NA	Reference^a	NA
65-74	111	44	441	112.9 (90.0-135.7)	.26	357.0 (297.8-416.2)	.78
75-84	186	56	456	119.6 (96.2-143.0)	.59	385.0 (326.8-443.2)	.51
≥85	258	86	519	171.4 (129.8-213.0)	.03	436.0 (368.4-503.6)	.04
Sex
Men	134	46	433	Reference^a	NA	Reference^a	NA
Women	165	53	470	126.7 (107.4-146.1)	.94	361.5 (325.0-398.0)	.83
Socioeconomic deprivation quintile
1 (least deprived)	136	44	414	Reference^a	NA	Reference^a	NA
2	148	51	464	139.9 (113.4-166.3)	.30	418.5 (357.1-479.9)	.09
3	131	45	441	137.3 (109.6-165.0)	.42	416.5 (356.6-476.4)	.10
4	138	53	436	136.0 (108.4-163.6)	.48	364.5 (315.2-413.8)	.97
5 (most deprived)	285	61	532	204.1 (151.0-257.3)	.004	443.0 (384.1-501.9)	.01
CCI score
0	100	39	344	Reference^a	NA	Reference^a	NA
1	215	51	491	206.9 (160.3-253.4)	.001	440.5 (382.6-498.4)	.01
2	237	90	512	212.9 (164.4-261.3)	<.001	418.5 (352.9-484.1)	.11
≥3	335	110	571	275.3 (210.6-340.0)	<.001	459.0 (396.3-521.7)	.003
IBS or DD
No	140	46	440	Reference^a	NA	Reference^a	NA
Yes	288	96	533	217.4 (154.4-280.5)	.005	469.5 (412.7-526.3)	<.001
Visits to GP 1-12 mo before cancer diagnosis, No.
0	601	24	671	416.7 (297.9-535.5)	<.001	559.0 (493.6-624.4)	<.001
1-4	35	21	119	25.1 (−0.2-50.5)	<.001	90.0 (20.9-159.1)	<.001
5-9	63	31	225	46.3 (23.0-69.5)	<.001	156.5 (101.0-212.0)	<.001
≥10	215	72	483	Reference^a	NA	Reference^a	NA
Type of symptom 24 mo before cancer diagnosis
Rectal bleeding or CIBH	134	42	464	Reference^a	NA	Reference^a	NA
Anemia (as only red flag)	167	54	442	123.4 (105.7-141.2)	.78	329.5 (293.5-365.5)	.05

Abbreviations: CCI, Charlson Comorbidity Index; CIBH, change in bowel habit; DD, diverticular disease; IBS, irritable bowel syndrome; MHM, mental health morbidity.

^{^a}

The reference group was men aged 55 to 64 years in the least socioeconomically deprived group with no comorbidities or MHM who had a CIBH or rectal bleeding. The adjusted interval for this group was 126.0 (95% CI, 94.5-157.5) for the fiftieth centile and 365.5 (95% CI, 288.6-442.4) for the seventy-fifth centile.