Figure 1.

Analysis of sex divergence in clinical measurements

(A) The fraction of each reported symptom for infected females (n = 137) and males (n = 1,033). Statistical significance was tested using the chi² independence test. Statistical significance: ^∗∗∗p < 0.001, ^∗∗p <0.01, ^∗p < 0.05.

(B) Initial viral load, measured by probe CT and averaged across the S, N, and ORF1ab genes, between females and males. Statistical significance was tested by the Kolmogorov-Smirnov test.

(C) Clinical data and biospecimens were collected longitudinally for each subject. Samples were labeled “baseline” if they tested negative for SARS-CoV-2, the first PCR-positive sample from each infected individual was labeled “first,” and any subsequent PCR-positive sample was labeled “mid.” Subjects were followed throughout infection, and any PCR-negative samples taken after infection were labeled “post.”