Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 1;13(11):924–931.e4. doi: 10.1016/j.cels.2022.10.005

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

PMC Copyright notice

Higher baseline ISG expression observed in females in CHARM and in reference datasets

(A) The majority of ISGs are significantly different between sexes in baseline samples. A subset of ISGs that remain statistically significant after cell type correction is shown (see Table S3 for full list), colored by the sex with higher expression. An orange marker represents genes with higher expression in females and blue represents genes with higher expression among males. Point size is proportional to the log fold change of expression between sexes.

(B–D) (B) ISGs are more highly expressed in females in CHARM baseline samples and two independent studies, (C) Depression Genes and Networks (DGN) (n = 922), and (D) Netherlands Study of Depression and Anxiety (NESDA) (n = 1,848). Vertical bars represent ISG locations among gene lists sorted by log fold change between females and males. Fold enrichment is a measure of the observed versus expected number of ISGs present at each gene rank. p values are computed from rank-based enrichment.