Figure 4.

Mediation analysis of the relationship between sex, ISGs, symptoms, and CD45 splice variant pre- and post-infection

(A) Causal mediation analysis was performed to test the mediation effects between pre-infection ISGs to post-infection molecular and clinical responses, as well as post-infection molecular responses to clinical responses. A stacked bar chart summarizes the full mediation results, with stars marking statistically significant mediation results (average causal mediation effect [ACME] p < 0.05).

(B) Pre-infection molecular and clinical measurements were separated from post-infection measurements. Selected significant results of mediation analysis were presented as a directed graph. Edges represent mediation or suppression effects.