Table 1. Summary Statistics of the Baseline Characteristics by Allocated Group of All Participants Who Progressed to the High-Dose Phase at 1 Month.
| Characteristic | No. (%) | ||
|---|---|---|---|
| Placebo (n = 109) | Simvastatin (n = 107) | Total (N = 216) | |
| Age, mean (SD), y | 64.8 (9.9) | 65.9 (8.6) | 65.3 (9.3) |
| Sex | |||
| Female | 49 (45) | 40 (37) | 89 (41) |
| Male | 60 (55) | 67 (63) | 127 (59) |
| Disease duration, mean (SD), y | 9.8 (4.6) | 9.5 (3.8) | 9.7 (4.2) |
| Systolic blood pressure, mean (SD), mm Hg | 128.9 (17.9) | 125.7 (16.3) | 127.3 (17.2) |
| BMI, mean (SD)a | 26.8 (4.7) | 26.2 (4.6) | 26.5 (4.7) |
| MoCA score, mean (SD) | 27.6 (2.4) | 27.6 (2.2) | 27.6 (2.3) |
| Ethnicityb | |||
| White | 108 (99) | 106 (99) | 214 (99) |
| Other | 1 (1) | 1 (1) | 2 (1) |
| Smoking status | |||
| Never | 76 (70) | 71 (66) | 147 (68) |
| Ex-smoker | 30 (27) | 32 (30) | 62 (29) |
| Light | 3 (3) | 3 (3) | 6 (3) |
| Moderate | 0 | 1 (1) | 1 (0.5) |
| Relationship status | |||
| Single | 7 (6) | 5 (5) | 12 (6) |
| Married or civil partnership | 89 (82) | 90 (84) | 179 (83) |
| Separated | 3 (3) | 1 (1) | 4 (2) |
| Divorced or partnership dissolved | 6 (6) | 7 (7) | 13 (6) |
| Widowed or surviving partner | 4 (4) | 4 (4) | 8 (4) |
| Living status | |||
| Live alone | 10 (9) | 12 (11) | 22 (10) |
| Live with spouse or partner | 95 (87) | 92 (86) | 187 (87) |
| Live with parent(s) | 1 (1) | 0 | 1 (0.5) |
| Live with children | |||
| <18 y | 10 (9) | 13 (12) | 23 (11) |
| ≥18 y | 17 (16) | 14 (13) | 31 (14) |
| Live with nonfamily | 1 (1) | 1 (1) | 2 (1) |
| QRISK2 risk score | |||
| ≥10% | 51 (47) | 49 (46) | 100 (46) |
| Median (IQR) | 9.2 (3.7-16.0) | 8.6 (5.8-15.9) | 9.0 (4.7-16.0) |
| Cholesterol, mean (SD), mg/dL | |||
| HDL | 61.8 (19.3) | 61.8 (19.3) | 61.8 (19.3) |
| Total | 189.2 (42.5) | 189.2 (38.6) | 189.2 (42.5) |
| Total/HDL ratio | 3.2 (1.0) | 3.3 (1.0) | 3.2 (1.0) |
| Hoehn and Yahr stage | |||
| 1.0-2.0 | 74 (68) | 75 (70) | 149 (69) |
| 2.5-3.0 | 35 (32) | 32 (30) | 67 (31) |
Abbreviations: BMI, body mass index; HDL, high-density lipoprotein; MoCA, Montreal Cognitive Assessment.
SI conversion factor: To convert cholesterol to mmol/L, multiply by 0.0259.
a
Calculated as weight in kilograms divided by height in meters squared.
b
Ethnicity was defined by investigators and assessed to facilitate description of the study sample. The other category included Indian and unreported.