Table 1. Demographics, Clinical, Psychosocial, and Neuropathologic Characteristics and Correlations With Scam Susceptibility.
| Factor | Mean (SD) | Correlation with scam susceptibilitya | P value |
|---|---|---|---|
| Demographics | |||
| Age at death, y | 91.3 (6.1) | 0.28 | <.001 |
| Men, No. (%) | 111 (27) | –0.29 | .77 |
| Women, No. (%) | 297 (73) | ||
| Education | 15.6 (3.1) | 0.05 | .27 |
| Cognition | |||
| Global cognition | –0.7 (1.0) | –0.35 | <.001 |
| Episodic memory | –0.6 (1.2) | –0.34 | <.001 |
| Semantic memory | –0.5 (1.1) | –0.35 | <.001 |
| Working memory | –0.5 (1.0) | –0.25 | <.001 |
| Visuospatial ability | –0.2 (1.0) | –0.28 | <.001 |
| Perceptual speed | –1.0 (0.9) | –0.37 | <.001 |
| Psychosocial factors | |||
| Depression | 1.6 (1.9) | –0.01 | .78 |
| Neuroticism | 15.0 (6.5) | 0.13 | .01 |
| Well-being | 5.2 (0.6) | –0.25 | <.001 |
| Purpose | 3.4 (0.5) | –0.06 | .21 |
| Anxiety | 1.3 (1.5) | 0.04 | .42 |
| Extraversion | 15.7 (3.1) | 0.01 | .87 |
| Vascular risk burden, No. (%) | |||
| Diabetes | 92 (23) | 1.39 | .17 |
| Hypertension | 285 (70) | –0.33 | .74 |
| Smoking | 162 (40) | 3.00 | .003 |
| Neuropathology, No. (%) | |||
| Macroscopic infarcts | 154 (38) | –2.79 | .006 |
| Microinfarcts | 163 (40) | –2.03 | .04 |
| Arteriolosclerosis (basal ganglia) | 100 (25) | –2.97 | .003 |
| CAA | 143 (35) | –0.79 | .43 |
| Atherosclerosis | 83 (20) | –2.41 | .02 |
| AD pathologic diagnosis | 256 (63) | –3.65 | .0003 |
| LATE-NC (stage 2/3) | 135 (33) | –3.05 | .002 |
| Lewy bodies | 104 (25) | –1.82 | .07 |
Abbreviations: AD, Alzheimer disease; CAA, cerebral amyloid angiopathy; LATE-NC, limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy.
a
Correlations derived from Spearman or t tests.