Figure 3. Patient Outcomes.

A, Overall patient outcomes after treatment changes were reported in question 13 of the case report form (eMethods in the Supplement). B, Patient outcomes after treatment changes were grouped according to positive outcomes, no change in outcomes, or negative outcomes and analyzed by the gene with diagnostic findings. Outcomes associated with the 11 genes with the highest frequency of diagnostic findings with reported follow-up after treatment changes are shown here. Outcomes for all genes with diagnostic findings that had clinical management changes reported and outcomes available are summarized in eTable 3 in the Supplement.