Fig. 2.
The SNARE complex. (A) Domain diagram of syntaxin‐1, SNAP‐25 and synaptobrevin with the length of each protein indicated by the number on the right, above each diagram. SNARE indicates SNARE motif. N‐pep, N‐peptide. (B) Ribbon diagrams of the NMR structure of the syntaxin‐1 Habc domain (orange) [48] (PDB accession code 1BR0) and the SNARE four‐helix bundle [13] (PDB accession code 1SFC) with syntaxin‐1 SNARE motif in yellow, SNAP‐25 in green and synaptobrevin in red. Acidic and basic side chains are shown as stick models and colored in red and blue, respectively. Selected side chains involved in Syt1 binding mentioned in the text are labeled. N indicates the N‐terminus of syntaxin‐1 and C the C‐termini of the SNARE motifs of syntaxin‐1, SNAP‐25 and synaptobrevin.