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. 2022 Jun 22;5(10):13862–13873. doi: 10.1021/acsanm.2c01632

Table 2. IC50 Values for the Cell Lines Incubated with the Samples for 72 ha.

  IC50(μg mL–1)
  MCF-7
PANC-1
HepG2
sample NPb(μg mL–1) equivc FUDR (μg mL–1) equiv CARB (μg mL–1) NP (μg mL–1) equiv FUDR (μg mL–1) equiv CARB (μg mL–1) NP (μg mL–1) equiv FUDR (μg mL–1) equiv CARB (μg mL–1)
MOF-808 - - - - - - - - -
FUDR@MOF-808 - - - - - - - - -
CARB@MOF-808 - - - 96.7 - 10.6 - - -
(FUDR+CARB)@MOF-808 45.9 0.27 4.2 17.8 0.11 1.6 42.3 0.25 3.9
PAAMAM@MOF-808 - - - - - - - - -
PAAMAM@(FUDR+CARB)@MOF-808 100 0.46 8.3 82.6 0.38 6.8 28.7 0.13 2.4
MOF-808_act - - - - - - - - -
FUDR@MOF-808_act - - - - - - - - -
CARB@MOF-808_act 39.4 - 5.4 8.4 - 1.2 24.0 - 3.3
(FUDR+CARB)@MOF-808_act 36.4 0.23 4.4 10.2 0.06 1.2 18.0 0.11 2.2
PAAMAM@MOF-808_act - - - - - - - - -
PAAMAM@(FUDR+CARB)@MOF-808_act - - - 94 0.65 9.0 18.5 0.13 1.8
FUDR - - - - 20.0 - - 14.0 -
CARB - - 59.4 - - -   - 15.8
PAAMAM - - - - - - - - -
a

Unreported values are the values that could not be determined in the used sample concentration range.

b

NP: nanoparticle;

c

equiv: equivalent.