TABLE 4.
Top 10 Bonferroni-significant CpG sites ranked by effect size from the meta-analysis of sex in child blood
| probeID | Effect Sizea | Standard Error | P-Value | Direction of effect in each cohortb | Chr. | Position | Nearest Gene |
|---|---|---|---|---|---|---|---|
| cg12691488 | 0.2137 | 0.001 | <5.0E-324 | +++++++++ | 1 | 243053673 | LINC01347 |
| cg00157199 | −0.2112 | 0.0051 | <5.0E-324 | --------- | 20 | 29551622 | FRG1BP |
| cg26921482 | −0.1938 | 0.0016 | <5.0E-324 | ------?-- | 16 | 2570283 | TBC1D24 |
| cg11388673 | 0.1692 | 0.0039 | <5.0E-324 | +++++++++ | 8 | 144371779 | ZNF696 |
| cg03151810 | 0.1588 | 0.0038 | <5.0E-324 | +++++++++ | 8 | 144371745 | ZNF696 |
| cg14361252 | −0.1503 | 0.0041 | 1.35E-286 | --?-?-?-- | 13 | 111465457 | LINC00346 |
| cg11092486 | −0.1439 | 0.0024 | <5.0E-324 | --------- | 6 | 5087604 | PPP1R3G |
| cg16810031 | −0.1404 | 0.0023 | <5.0E-324 | -?----?-- | 17 | 38024146 | ZPBP2 |
| cg14815891 | −0.1394 | 0.0048 | 3.41E-182 | -?------- | 20 | 29611903 | FRG1BP |
| cg01066472 | −0.1297 | 0.0041 | 1.28E-218 | --------- | 1 | 75591029 | LHX8 |
a
negative effect size indicates lower methylation in boys compared to girls
b
For each cohort participating in the analysis, + indicates a positive direction of effect, - indicates a negative direction of effect, and ? indicates missing data for that CpG site in that specific cohort. The cohort order is: ALSPAC, BAMSE, CHAMACOS, CHOP, Generation R, HELIX, IOW F1, and Viva.