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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Colloids Surf B Biointerfaces. 2021 Jun 29;206:111952. doi: 10.1016/j.colsurfb.2021.111952

Fig. 5.

Fig. 5.

A: Body weight assessment. Twenty-one days after antigen induction of RA, the animals were treated daily with HCQ + MTX, 127-Pluronic–HCQ-MTX nanomicelles 1 or 127-Pluronic–HCQ-MTX nanomicelles 2 via i.p. for seven days. The animals in the control group (sham) and in the immunized group (mBSA) were administered intraperitoneally with sterile saline. The animals in the vehicle group were administered intraperitoneally with Pluronic 10 %. The results are presented as the mean of the differences between pre-treatment and post-treatment weight (Δ) ± SEM of five mice per group. 5B:127-Pluronic–HCQ-MTX nanomicelles reduces antigen-induced edema. Knee joint edema was assessed by measuring the transverse diameter of thefemur-tibial joint with the aid of a digital caliper (Digmatic caliper, Mitutoyo Corp. Kanagawa, Japan). The edema values were expressed by the difference (Δ) between the diameters measured before (baseline) and after ± SEM treatment and were represented in millimeters (mm). +++ p < 0.001 compared to sham group; *** p < 0.001 compared to mBSA group.